Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 10/20 | 0.57 |
| ▸ | MMP13 | P45452 | 4/20 | 0.57 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6368918 | 0.87 | MMP12 (0.74) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6369477 | 0.87 | MMP12 (0.74) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL8301905 | 0.84 | MMP12 (0.78) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6367846 | 0.80 | MMP12 (0.76) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL8300063 | 0.80 | MMP12 (0.76) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6505161 | 0.77 | MMP12 (0.57) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6367844 | 0.75 | MMP12 (0.51) | MMP12MMP13MMP3MMP9MMP8 | |
| Propionic Acid SCHEMBL6509431 | 0.74 | MMP12 (0.48) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL3923931 | 0.74 | SMN1; SMN2 (0.59) | MMP8SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8302059 | 0.73 | MMP12 (0.76) | MMP12MMP13MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003115-A1 | THIOPHENE AMINO ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |