Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 6/20 | 0.76 |
| ▸ | MMP13 | P45452 | 3/20 | 0.76 |
| ▸ | MMP3 | P08254 | 1/20 | 0.76 |
| ▸ | MMP9 | P14780 | 1/20 | 0.76 |
| ▸ | MMP8 | P22894 | 1/20 | 0.76 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.50 |
| ▸ | AKT1 | P31749 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.50 |
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.50 |
| ▸ | RPS6KA5 | O75582 | 4/20 | 0.50 |
| ▸ | NEK4 | P51957 | 4/20 | 0.50 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.50 |
| ▸ | PRKG2 | Q13237 | 4/20 | 0.50 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.50 |
| ▸ | GSK3A | P49840 | 4/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.50 |
| ▸ | PRKCG | P05129 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8298104 | 0.86 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL4321262 | 0.86 | MMP12 (1.00) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL8300026 | 0.86 | MMP12 (0.66) | MMP12MMP13MMP3MMP9MMP8 | |
| Hydrochloric Acid SCHEMBL6662154 | 0.85 | MMP12 (0.98) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6388429 | 0.84 | MMP12 (0.78) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6367846 | 0.76 | MMP12 (0.76) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL8300063 | 0.76 | MMP12 (0.76) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL8301127 | 0.73 | MMP12 (0.57) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6367899 | 0.73 | MMP12 (0.73) | MMP12MMP13MMP3MMP9MMP8 | |
| SCHEMBL6388987 | 0.72 | MMP12 (0.79) | MMP12MMP13MMP3MMP9MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005003115-A1 | THIOPHENE AMINO ACID DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | WARNER-LAMBERT COMPANY LLC (US) | 2005-01-13 | — | — | WO | disclosed |