Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 1/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11014056 | 0.88 | AKR1C2 (0.68) | AKR1C2MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL19749132 | 0.84 | AKR1C2 (0.48) | AKR1C2MTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL7962079 | 0.83 | NQO2 (0.66) | NQO2AKR1C2MTNR1AMTNR1BMEN1 | |
| SCHEMBL19749133 | 0.77 | KDM4E (0.67) | MTNR1AMTNR1BMEN1KMT2AKDM4E | |
| SCHEMBL8301133 | 0.76 | PLA2G2A (0.75) | MEN1KMT2AALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL11090385 | 0.74 | MEN1 (0.53) | NQO2AKR1C2MTNR1AMTNR1BMEN1 | |
| SCHEMBL28484096 | 0.73 | TRPM8 (0.64) | AKR1C2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7964053 | 0.73 | PLA2G2A (0.76) | KMT2AMAPK1PTGS2PLA2G2A | |
| SCHEMBL21336442 | 0.73 | L3MBTL1 (0.65) | MEN1KMT2AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL5605077 | 0.72 | AKR1C2 (0.74) | NQO2AKR1C2MTNR1AMTNR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620214-B1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | LILLY CO ELI (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5578634-A | SEPTIC SHOCK TREATMENT | ELI LILLY AND COMPANY (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0620214-A1 | 1H-indole-3-acetic acid hydrazide sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |