Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.66 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 8/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10613665 | 0.86 | SIRT1 (0.52) | NQO2ALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL30604527 | 0.85 | AKR1C2 (0.78) | NQO2AKR1C2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL6825151 | 0.85 | AKR1C2 (0.78) | NQO2AKR1C2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL8301359 | 0.83 | NQO2 (0.54) | NQO2AKR1C2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7964163 | 0.83 | HTR6 (0.60) | NQO2AKR1C2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL6703468 | 0.83 | KDM4E (0.69) | AKR1C2ALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL27540490 | 0.81 | PTGS2 (0.57) | NQO2AKR1C2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL7952945 | 0.81 | HTR6 (0.62) | NQO2AKR1C2MTNR1AMTNR1BALDH1A1 | |
| SCHEMBL1774151 | 0.80 | NQO2 (1.00) | NQO2MTNR1AMTNR1BALDH1A1HSD17B10 | |
| SCHEMBL7953435 | 0.80 | MTNR1A (0.62) | NQO2AKR1C2MTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |