Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 1/20 | 0.51 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17373973 | 0.93 | MEN1 (0.67) | ALDH1A1MEN1KMT2APOLBCYP19A1 | |
| Hydrochloric Acid SCHEMBL2140664 | 0.83 | HTR7 (0.69) | ALDH1A1MEN1KMT2APOLBHTR7 | |
| SCHEMBL8298907 | 0.81 | HTR7 (0.56) | ALDH1A1POLBL3MBTL1HTR7HTR6 | |
| SCHEMBL5813426 | 0.81 | ALDH1A1 (0.87) | ALDH1A1MEN1KMT2APOLBCYP19A1 | |
| SCHEMBL2034554 | 0.80 | KMT2A (0.78) | ALDH1A1MEN1KMT2APOLBCYP19A1 | |
| SCHEMBL4222537 | 0.80 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2APOLBHTR7 | |
| Hydrochloric Acid SCHEMBL4232329 | 0.80 | HTR7 (0.70) | ALDH1A1MEN1KMT2APOLBHTR7 | |
| SCHEMBL4616665 | 0.80 | SFRP1 (0.65) | ALDH1A1POLBL3MBTL1HTR7HTR6 | |
| Dinsed SCHEMBL1814194 | 0.80 | KMT2A (1.00) | ALDH1A1MEN1KMT2APOLBCYP19A1 | |
| Hydrochloric Acid SCHEMBL4230045 | 0.79 | HTR7 (0.69) | ALDH1A1MEN1KMT2APOLBHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| EP-1781659-B1 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-05 | — | — | EP | disclosed |
| WO-2005012304-A2 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-10 | — | — | WO | disclosed |