Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 11/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.50 |
| ▸ | HTR6 | P50406 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17374111 | 0.92 | PRMT1 (0.54) | HTR7L3MBTL1PRMT1ALDH1A1HTR2A | |
| SCHEMBL4616665 | 0.84 | SFRP1 (0.65) | HTR7L3MBTL1TDP1ALDH1A1MBTD1 | |
| SCHEMBL2850490 | 0.82 | L3MBTL1 (0.58) | L3MBTL1PRMT1MBTD1 | |
| SCHEMBL14419669 | 0.81 | CYP3A4 (0.58) | HTR7L3MBTL1ALDH1A1MBTD1POLB | |
| SCHEMBL8301568 | 0.81 | ALDH1A1 (0.78) | HTR7L3MBTL1ALDH1A1MBTD1HTR6 | |
| SCHEMBL2854997 | 0.81 | SIGMAR1 (0.59) | L3MBTL1PRMT1 | |
| SCHEMBL1361813 | 0.79 | ALDH1A1 (0.64) | TDP1PRMT1ALDH1A1POLB | |
| SCHEMBL922624 | 0.78 | PRMT1 (0.62) | PRMT1ALDH1A1POLB | |
| SCHEMBL12672472 | 0.78 | HTR7 (0.83) | HTR7L3MBTL1ALDH1A1MBTD1HTR2A | |
| SCHEMBL1565027 | 0.78 | PRMT1 (0.73) | TDP1PRMT1ALDH1A1HTR6POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| US-7449465-B2 | Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-11-11 | — | — | US | disclosed |
| EP-1781659-B1 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-05 | — | — | EP | disclosed |
| WO-2005012304-A2 | TRIAZOLOPYRIMIDINE DERIVATIVES AS GLYCOGEN SYNTHASE KINASE 3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-10 | — | — | WO | disclosed |