Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8301375 | 0.87 | NLRP3 (0.53) | LMNAGAAHPGD | |
| SCHEMBL8292287 | 0.83 | GAA (0.57) | LMNAKDM4EGAAALDH1A1HPGD | |
| SCHEMBL8299247 | 0.81 | PDE5A (0.53) | NPC1LMNAGAAHPGDMEN1 | |
| SCHEMBL6944281 | 0.81 | GAA (0.55) | LMNASMN1; SMN2KDM4EGAAALDH1A1 | |
| SCHEMBL8301784 | 0.80 | POLB (0.46) | NPC1LMNASMN1; SMN2KDM4EPOLB | |
| SCHEMBL8301788 | 0.80 | POLB (0.46) | NPC1LMNASMN1; SMN2KDM4EPOLB | |
| SCHEMBL8299255 | 0.78 | PDE5A (0.53) | LMNAGAAHPGD | |
| SCHEMBL24254492 | 0.77 | NPC1 (0.61) | NPC1LMNASMN1; SMN2KDM4EGAA | |
| SCHEMBL8297189 | 0.77 | GAA (0.55) | LMNAGAAHPGDMEN1KMT2A | |
| SCHEMBL17241767 | 0.76 | GAA (0.57) | LMNAKDM4EGAAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0686625-B1 | ANTHRANILIC ACID DERIVATIVE | EISAI CO LTD (JP) | 1999-05-26 | — | — | EP | disclosed |
| US-5716993-A | PHOSPHODIESTERASE ENZYME INHIBITOR FOR TREATING CARDIOVASCULAR DISORDER, ANGINA PECTORIS, HYPERTENSION, ASTHMA | EISAI CO., LTD. (JP) | 1998-02-10 | — | — | US | disclosed |
| CN-1118595-A | Anthranilic acid derivative | EISAI CO LTD (JP) | 1996-03-13 | — | — | CN | disclosed |
| EP-0686625-A1 | ANTHRANILIC ACID DERIVATIVE | Eisai Co., Ltd. (JP) | 1995-12-13 | — | — | EP | disclosed |