Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | CBS | P35520 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306406 | 0.82 | TRPV1 (0.43) | TRPV1SMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL6925637 | 0.81 | TRPV1 (0.39) | TRPV1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL8338426 | 0.81 | DRD2 (0.42) | TRPV1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6927639 | 0.80 | TAS1R3 (0.44) | TRPV1SMN1; SMN2LMNARAB9AMEN1 | |
| SCHEMBL6921675 | 0.80 | TAS1R3 (0.46) | TRPV1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL6929369 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8305219 | 0.79 | GAA (0.46) | SMN1; SMN2RAB9AMEN1KMT2AGAA | |
| SCHEMBL6925067 | 0.79 | MAPT (0.44) | TRPV1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7069222 | 0.79 | NPC1 (0.50) | TRPV1LMNANPC1RAB9AMEN1 | |
| SCHEMBL6765702 | 0.76 | SIGMAR1 (0.51) | SMN1; SMN2LMNANOD1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925300-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0925300-A4 | — | — | 1999-06-30 | — | — | EP | claimed |
| WO-1997030054-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-08-21 | — | — | WO | claimed |