Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | FAAH | O00519 | 6/20 | 0.55 |
| ▸ | LTA4H | P09960 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6721335 | 0.85 | RECQL (0.75) | RECQLKMT2AMEN1NPC1RAB9A | |
| SCHEMBL15203359 | 0.82 | KMT2A (0.62) | KMT2AMEN1NPC1RAB9AGAA | |
| SCHEMBL22069657 | 0.82 | RECQL (1.00) | RECQLKMT2AMEN1HPGDSMN1; SMN2 | |
| SCHEMBL27852723 | 0.80 | RECQL (0.74) | RECQLKMT2AMEN1HPGDGAA | |
| SCHEMBL6725374 | 0.80 | NR1H4 (0.61) | KMT2AMEN1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5105487 | 0.79 | LMNA (0.57) | SMN1; SMN2FAAHLMNAKDM4EALDH1A1 | |
| SCHEMBL8495474 | 0.78 | LTA4H (0.55) | RECQLKMT2AMEN1NPC1RAB9A | |
| SCHEMBL31022551 | 0.77 | GAA (0.67) | SMN1; SMN2GAAL3MBTL1FAAHLMNA | |
| SCHEMBL401828 | 0.77 | RECQL (0.66) | RECQLKMT2AMEN1HPGDNPC1 | |
| SCHEMBL5864374 | 0.76 | RECQL (0.69) | RECQLKMT2AMEN1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089915-A1 | PIPERAZINE DERIVATIVE RENIN INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | disclosed |