Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | LTA4H | P09960 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | RNF4 | P78317 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | GAA | P10253 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.55 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.55 |
| ▸ | GLA | P06280 | 1/20 | 0.54 |
| ▸ | MGLL | Q99685 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22069595 | 0.87 | RECQL (0.77) | RECQLLTA4HALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL27852723 | 0.86 | RECQL (0.74) | RECQLLTA4HALDH1A1KDM4EMEN1 | |
| SCHEMBL22069565 | 0.86 | RECQL (0.75) | RECQLLTA4HALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6721335 | 0.86 | RECQL (0.75) | RECQLLTA4HALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL22069745 | 0.83 | RECQL (0.71) | RECQLLTA4HALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5316075 | 0.83 | LTA4H (1.00) | RECQLLTA4HALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8302598 | 0.82 | RECQL (0.70) | RECQLLTA4HALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5864374 | 0.82 | RECQL (0.69) | RECQLALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL18657627 | 0.81 | RAB9A (0.74) | RECQLALDH1A1SMN1; SMN2RNF4MEN1 | |
| SCHEMBL22069728 | 0.81 | KDM4E (0.74) | RECQLLTA4HALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |
| EP-3666769-A1 | NOVEL CASPASE INHIBITORS | RIJKSUNIVERSITEIT GRONINGEN (NL) | 2020-06-17 | — | — | EP | disclosed |