Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.56 |
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | HTR7 | P34969 | 4/20 | 0.55 |
| ▸ | HTR1D | P28221 | 6/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.51 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.49 |
| ▸ | HTR6 | P50406 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8443108 | 0.95 | HTR1A (0.60) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL8298849 | 0.92 | DRD2 (0.60) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL8298238 | 0.90 | SLC6A4 (0.47) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL8296789 | 0.87 | HTR1A (0.62) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL8303049 | 0.86 | DRD2 (0.67) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL8298953 | 0.84 | HTR1A (0.50) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL29534522 | 0.84 | HTR1A (0.56) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL8297151 | 0.84 | SLC6A4 (0.48) | OPRM1OPRK1OPRL1HTR1AHTR7 | |
| SCHEMBL8572323 | 0.82 | HTR1D (0.49) | HTR1AHTR1DDRD2HTR1BCHRM2 | |
| SCHEMBL8442346 | 0.81 | OPRM1 (0.56) | OPRM1OPRK1OPRL1HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |