Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | NSD2 | O96028 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30006467 | 0.83 | LMNA (0.51) | KMT2ALMNAALDH1A1L3MBTL1HTT | |
| SCHEMBL3855094 | 0.83 | LMNA (0.51) | KMT2ALMNAALDH1A1L3MBTL1HTT | |
| SCHEMBL14536599 | 0.83 | POLB (0.49) | KMT2AALDH1A1L3MBTL1POLBHTT | |
| SCHEMBL5928422 | 0.83 | ALDH1A1 (0.48) | KMT2ALMNAALDH1A1L3MBTL1NSD2 | |
| SCHEMBL6246429 | 0.82 | AKR1C3 (0.48) | KMT2ALMNAALDH1A1L3MBTL1PPARA | |
| SCHEMBL6244788 | 0.81 | L3MBTL1 (0.43) | KMT2ALMNAALDH1A1L3MBTL1NSD2 | |
| SCHEMBL5529874 | 0.80 | MAPT (0.56) | KMT2ALMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL4702681 | 0.80 | MAPT (0.56) | KMT2ALMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL6417389 | 0.79 | LMNA (0.62) | KMT2ALMNAALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL6273186 | 0.79 | ESR1 (0.50) | KMT2ALMNAALDH1A1L3MBTL1NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009995-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |