Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | ASPH | Q12797 | 1/20 | 0.33 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CFD | P00746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9688329 | 0.83 | TDP1 (0.45) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL17374953 | 0.83 | TDP1 (0.47) | KDM4EUSP2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL8307045 | 0.78 | — | — | |
| SCHEMBL7520417 | 0.75 | TDP1 (0.46) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL4853079 | 0.74 | KDM4E (0.38) | KDM4EUSP2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL17374983 | 0.74 | CSNK2A1 (0.44) | KDM4EUSP2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL753289 | 0.72 | KEAP1 (0.46) | KDM4EUSP2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL14691383 | 0.72 | TDP1 (0.53) | KDM4EUSP2ALDH1A1HPGDCYP2C19 | |
| SCHEMBL9487223 | 0.70 | KDM4E (0.35) | KDM4EUSP2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4339765 | 0.70 | ALDH1A1 (0.36) | KDM4EALDH1A1HSD17B10TDP1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0832078-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040659-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |