⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9614493 | 0.79 | MEN1 (0.34) | — | |
| SCHEMBL8303437 | 0.78 | KDM4E (0.36) | — | |
| SCHEMBL31265698 | 0.73 | POLB (0.33) | — | |
| SCHEMBL9688329 | 0.69 | TDP1 (0.45) | — | |
| SCHEMBL1594594 | 0.68 | ALDH1A1 (0.53) | — | |
| SCHEMBL28480863 | 0.66 | ALOX15 (0.33) | — | |
| SCHEMBL22279635 | 0.64 | KCNH2 (0.37) | — | |
| SCHEMBL8924350 | 0.64 | RIPK1 (0.33) | — | |
| SCHEMBL4847810 | 0.64 | PIM1 (0.45) | — | |
| SCHEMBL6484325 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |
| US-5814648-A | N-hydroxyureas as antiinflammatory agents | PFIZER INC. (US) | 1998-09-29 | — | — | US | disclosed |
| EP-0832078-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040659-A1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1996-12-19 | — | — | WO | disclosed |