Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304153 | 0.89 | HTR1A (0.48) | PARP1SIGMAR1DRD2KCNH2PARP2 | |
| SCHEMBL8300847 | 0.84 | PARP1 (0.39) | PARP1DRD2DRD4DRD3KCNH2 | |
| SCHEMBL8300861 | 0.84 | PARP1 (0.42) | PARP1DRD2DRD4DRD3KCNH2 | |
| SCHEMBL8628752 | 0.78 | KDM4E (0.54) | PARP1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL8299419 | 0.78 | DRD2 (0.38) | PARP1SIGMAR1DRD2DRD4DRD3 | |
| SCHEMBL8303694 | 0.77 | DRD2 (0.46) | DRD2DRD4DRD3 | |
| SCHEMBL8299061 | 0.77 | DRD2 (0.46) | DRD2DRD4DRD3 | |
| SCHEMBL8299447 | 0.76 | MEN1 (0.51) | PARP1SIGMAR1DRD2HTR1A | |
| SCHEMBL8296824 | 0.74 | CD44 (0.48) | PARP1DRD2DRD4DRD3 | |
| SCHEMBL25293094 | 0.74 | HTR6 (0.44) | PARP1SIGMAR1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | claimed |
| EP-0701555-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-03-20 | — | — | EP | claimed |
| WO-1994021626-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | claimed |
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | disclosed |
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |