Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.47 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1550145 | 0.83 | CHRM5 (0.46) | CHRM5TRPV3SCN10A | |
| SCHEMBL3409448 | 0.80 | DYRK1A (0.50) | DYRK1ATRPV3XDHFYNKCNH2 | |
| SCHEMBL8350438 | 0.79 | DYRK1A (0.52) | DYRK1AXDHFYNKCNH2SCN10A | |
| SCHEMBL4591309 | 0.79 | MAOB (0.53) | KCNH2 | |
| SCHEMBL21034957 | 0.79 | KDM1A (0.47) | PIM1CHRM5TRPV3FYN | |
| SCHEMBL31356744 | 0.78 | ALDH1A1 (0.48) | DYRK1ACHRM5XDHFYNKCNH2 | |
| SCHEMBL5510433 | 0.78 | ABL1 (0.54) | PIM1DYRK1A | |
| SCHEMBL8309977 | 0.77 | LDHA (0.57) | DYRK1AXDHFYN | |
| SCHEMBL17954210 | 0.74 | CYP4F2 (0.49) | DYRK1AFYN | |
| SCHEMBL31356676 | 0.74 | FYN (0.47) | DYRK1ATRPV3XDHFYNKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872136-A | Arylheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0891361-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036901-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |