Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.65 |
| ▸ | CASP6 | P55212 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.48 |
| ▸ | CES1 | P23141 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4298833 | 0.87 | ATM (0.60) | ATMALDH1A1SMN1; SMN2PLAUTHRB | |
| SCHEMBL3110750 | 0.87 | ALDH1A1 (0.71) | ATMALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL8305931 | 0.82 | KDM4E (0.57) | ATMCASP6ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8305888 | 0.82 | CASP6 (0.53) | ATMCASP6ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL8300884 | 0.82 | CASP6 (0.49) | ATMCASP6ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8446688 | 0.81 | ALDH1A1 (0.60) | ATMCASP6ALDH1A1SMN1; SMN2THRB | |
| SCHEMBL8305961 | 0.81 | ALDH1A1 (0.50) | ATMCASP6ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7379932 | 0.80 | ATM (0.75) | ATMALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL8304450 | 0.80 | CASP6 (0.47) | ATMCASP6ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL8303927 | 0.79 | MEN1 (0.62) | CASP6ALDH1A1SMN1; SMN2THRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | claimed |
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |