Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302750 | 0.86 | CASP6 (0.48) | CASP6ALDH1A1SMN1; SMN2HCAR3PDK1 | |
| SCHEMBL8300884 | 0.84 | CASP6 (0.49) | CASP6ALDH1A1SMN1; SMN2HCAR3POLB | |
| SCHEMBL8305961 | 0.83 | ALDH1A1 (0.50) | CASP6ALDH1A1SMN1; SMN2HCAR3MAPT | |
| SCHEMBL8302742 | 0.82 | ALDH1A1 (0.50) | CASP6ALDH1A1SMN1; SMN2HCAR3PDK1 | |
| SCHEMBL8305931 | 0.82 | KDM4E (0.57) | CASP6ALDH1A1SMN1; SMN2HCAR3POLB | |
| SCHEMBL8442696 | 0.81 | ALDH1A1 (0.48) | CASP6ALDH1A1SMN1; SMN2HCAR3MAPT | |
| SCHEMBL8306053 | 0.80 | ALDH1A1 (0.48) | CASP6ALDH1A1SMN1; SMN2HCAR3PDK1 | |
| SCHEMBL8303776 | 0.80 | ATM (0.65) | CASP6ALDH1A1SMN1; SMN2HCAR3KMT2A | |
| SCHEMBL8300946 | 0.79 | ALDH1A1 (0.47) | CASP6ALDH1A1SMN1; SMN2HCAR3PDK1 | |
| SCHEMBL8306989 | 0.79 | ALDH1A1 (0.44) | CASP6ALDH1A1SMN1; SMN2HCAR3PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | claimed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | claimed |
| EP-0934068-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998009630-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-03-12 | — | — | WO | disclosed |