Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TDP2 | O95551 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | GALK1 | P51570 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305161 | 0.87 | NOTUM (0.54) | ALDH1A1SMN1; SMN2USP30TSHRNPC1 | |
| SCHEMBL16131376 | 0.84 | RAB9A (0.60) | ALDH1A1SMN1; SMN2RAB9ATSHRNPC1 | |
| SCHEMBL8305710 | 0.81 | ALDH1A1 (0.51) | ALDH1A1NPSR1SMN1; SMN2USP30RAB9A | |
| SCHEMBL3529467 | 0.78 | NOTUM (0.64) | ALDH1A1NPSR1KDM4ESMN1; SMN2PKM | |
| SCHEMBL1661083 | 0.77 | NPC1 (0.60) | ALDH1A1NPSR1KDM4EPKMTSHR | |
| Benzene SCHEMBL28217786 | 0.77 | NOTUM (0.62) | ALDH1A1NPSR1KDM4ESMN1; SMN2PKM | |
| Hydrochloric Acid SCHEMBL28060567 | 0.77 | NOTUM (0.62) | ALDH1A1NPSR1KDM4ESMN1; SMN2PKM | |
| SCHEMBL5104476 | 0.74 | USP30 (0.51) | ALDH1A1NPSR1KDM4EUSP30RAB9A | |
| SCHEMBL5326027 | 0.74 | ITGB3 (0.45) | ALDH1A1KDM4ECYP2C19TSHRPOLB | |
| Cadaverine Tartrate SCHEMBL29195643 | 0.74 | POLB (0.40) | ALDH1A1SMN1; SMN2USP30RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965578-A | Inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0897303-A4 | — | — | 1999-02-24 | — | — | EP | disclosed |
| EP-0897303-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-02-24 | — | — | EP | disclosed |
| WO-1997036605-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |