Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.45 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30598448 | 0.88 | ALDH1A1 (0.43) | KDM4EUSP2CYP3A4ALDH1A1HPGD | |
| SCHEMBL4574807 | 0.88 | ALDH1A1 (0.43) | KDM4EUSP2CYP3A4ALDH1A1HPGD | |
| SCHEMBL8307482 | 0.85 | AKT1 (0.56) | AKT1PRSS1PRSS2PRSS3GABRP | |
| SCHEMBL8309333 | 0.84 | CYP1B1 (0.57) | PDE4DAKT1USP2CYP3A4APP | |
| SCHEMBL8308207 | 0.84 | AKT1 (0.61) | DYRK1ADYRK1BPDE5AESR1PDE4D | |
| SCHEMBL8305241 | 0.84 | KDM4E (0.52) | DYRK1ADYRK1BPARP1PARP2KDM4E | |
| SCHEMBL8308046 | 0.82 | MAOB (0.52) | USP2CYP3A4PPARGKDM1APTGS2 | |
| SCHEMBL8429377 | 0.81 | ALDH1A1 (0.39) | KDM4EUSP2CYP3A4ACHEPLK1 | |
| SCHEMBL19354056 | 0.80 | PDE5A (0.61) | DYRK1ADYRK1BPDE5AESR1PDE4D | |
| SCHEMBL8308751 | 0.79 | PTGS1 (0.41) | KDM4ECYP3A4PTGS2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| US-5629339-A | CHRONIC VENOUS INSUFFICIENCY | ADIR ET COMPAGNIE (FR) | 1997-05-13 | — | — | US | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |