Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | PARP1 | P09874 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HBB | P68871 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299074 | 0.89 | PARP1 (0.46) | HTR1ADRD2PARP1SIGMAR1KCNH2 | |
| SCHEMBL8299447 | 0.88 | MEN1 (0.51) | HTR1ADRD2PARP1MEN1KMT2A | |
| SCHEMBL8299045 | 0.83 | HTR1A (0.56) | HTR1ADRD2PARP1MEN1KMT2A | |
| SCHEMBL8304196 | 0.83 | MEN1 (0.49) | HTR1ADRD2PARP1MEN1KMT2A | |
| SCHEMBL8630660 | 0.80 | TSHR (0.52) | DRD2MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8300847 | 0.80 | PARP1 (0.39) | HTR1ADRD2PARP1HTR2AKCNH2 | |
| SCHEMBL8300861 | 0.79 | PARP1 (0.42) | DRD2PARP1KDM4EGAAMAPT | |
| SCHEMBL8299419 | 0.73 | DRD2 (0.38) | HTR1ADRD2PARP1KMT2ASIGMAR1 | |
| SCHEMBL238334 | 0.73 | MEN1 (0.66) | HTR1ADRD2MEN1KMT2ASIGMAR1 | |
| SCHEMBL8299061 | 0.73 | DRD2 (0.46) | DRD2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | claimed |
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | disclosed |
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |
| EP-0701555-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-03-20 | — | — | EP | disclosed |
| WO-1994021626-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | disclosed |