Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 5/20 | 0.42 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HBB | P68871 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299447 | 0.89 | MEN1 (0.51) | MEN1KMT2ASIGMAR1PARP1HTR1A | |
| SCHEMBL8304153 | 0.83 | HTR1A (0.48) | MEN1KMT2ASIGMAR1PARP1HTR1A | |
| SCHEMBL8630130 | 0.81 | MAPT (0.47) | MEN1KMT2APARP1DRD2KDM4E | |
| SCHEMBL8299045 | 0.80 | HTR1A (0.56) | MEN1KMT2ASIGMAR1PARP1HTR1A | |
| SCHEMBL8299074 | 0.72 | PARP1 (0.46) | SIGMAR1PARP1HTR1ADRD2 | |
| SCHEMBL238334 | 0.69 | MEN1 (0.66) | MEN1KMT2ASIGMAR1HTR1ADRD2 | |
| SCHEMBL11823875 | 0.69 | SIGMAR1 (0.60) | MEN1KMT2ASIGMAR1PARP1HTR1A | |
| Hydrochloric Acid SCHEMBL29662083 | 0.68 | SIGMAR1 (0.56) | MEN1KMT2ASIGMAR1PARP1HTR1A | |
| SCHEMBL5542167 | 0.68 | SIGMAR1 (0.56) | MEN1KMT2ASIGMAR1PARP1HTR1A | |
| SCHEMBL8628174 | 0.68 | HSD17B10 (0.52) | MEN1KMT2APARP1DRD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | claimed |
| EP-0701555-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LTD. (GB) | 1996-03-20 | — | — | EP | claimed |
| WO-1994021626-A1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME LIMITED (GB) | 1994-09-29 | — | — | WO | claimed |
| EP-0701555-B1 | INDAZOLE DERIVATIVES | MERCK SHARP & DOHME (GB) | 1999-08-04 | — | — | EP | disclosed |
| US-5665732-A | Indazole derivatives | MERCK, SHARP & DOHME LTD. (GB) | 1997-09-09 | — | — | US | disclosed |