SCHEMBL8304162

SCHEMBL8304162

COc1nc(C)nc(NC(=O)c2ccccc2S(N)(=O)=O)n1

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA1 P00915 9/20 0.50
CA2 P00918 9/20 0.50
CA9 Q16790 9/20 0.50
CA5A P35218 1/20 0.50
CA12 O43570 2/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
BCAT2 O15382 1/20 0.39
MAPK1 P28482 1/20 0.39
THRB P10828 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28457469 0.89 CA2 (0.40) CA1CA2CA9CA5ACA12
SCHEMBL10914174 0.89 KMT2A (0.42) CA1CA2CA9CA5ACA12
SCHEMBL9775343 0.82 KMT2A (0.39) CA1CA2CA9MEN1KMT2A
SCHEMBL8589747 0.82 MEN1 (0.36) CA1CA2CA9CA5ACA12
SCHEMBL2369909 0.80 KMT2A (0.47) MEN1KMT2AMAPK1
SCHEMBL10922660 0.78 ALDH1A1 (0.42) CA1CA2CA9MEN1KMT2A
SCHEMBL10749518 0.77 STAT3 (0.47) CA1CA2CA9CA5ACA12
SCHEMBL30297961 0.77 MEN1 (0.42) CA1CA2CA9CA5ACA12
SCHEMBL8740203 0.76 EDNRA (0.42) CA1CA2CA9CA5AMEN1
SCHEMBL11002649 0.76 NPC1 (0.45) THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5718079-A ALTERED ACETOHYDROXYACID SYNTHASE ENZYMES MGI PHARMA, INC. (US) 1998-02-17 US claimed
EP-4593598-A1 STORAGE-STABLE COMPOSITIONS INCLUDING BIXLOZONE AND BEFLUBUTAMID FMC Corporation (US) 2025-08-06 EP disclosed
US-12203090-B2 Polynucleotides and methods for transferring resistance to Asian soybean rust Two Blades Fpondation (US) 2025-01-21 US disclosed
WO-2024073019-A1 STORAGE-STABLE COMPOSITIONS INCLUDING BIXLOZONE AND B EFLUB UT AMID FMC CORPORATION (US) 2024-04-04 WO disclosed
US-20230157232-A1 Polynucleotides And Methods For Transferring Resistance To Asian Soybean Rust CORTEVA AGRISCIENCE LLC 2023-05-25 US disclosed
EP-4138556-A1 LIQUID SULFONYLUREA HERBICIDE COMPOSITION Battelle UK Limited (GB) 2023-03-01 EP disclosed
US-H1785-H PRE- AND POST-EMERGENCE HERBICIDE FMC CORPORATION (US) 1999-02-02 US disclosed
US-H1759-H NEW HERBICIDE MOLECULAR COMPRISING A RING SELECT FROM THE GROUP OF PYRIMIDINE, TRIAZOLE, PYRAZOLE, ISOINDOLE, THIADIAZOLO(3,4-A)PYRIDAZINE, TRIAZINE(1,2,4), INDAZOLE, TETRAZOLE, TRIAZOLE(4,3-A)PYRIDINE FMC CORPORATION (US) 1998-11-03 US disclosed
US-5726124-A IN MIXTURE WITH OTHER HERBICIDES, ALKYLATION AND ETHERIFICATION OF PYRIMIDINONE AND THIOPYRIMIDINONE COMPOUNDS ROHM AND HAAS COMPANY (US) 1998-03-10 US disclosed
US-5688745-A Arylsulfonylureas and their use as herbicides and growth regulators HOECHST AKTIENGESELLSCHAFT (DE) 1997-11-18 US disclosed
EP-0264672-A2 Phenylsulfonyl isourea BAYER AG (DE) 1988-04-27 EP disclosed
EP-0264021-A2 0-Aryl-N'-(triazin-2-yl)-isourea BAYER AG (DE) 1988-04-20 EP disclosed
EP-0235558-A2 5-Amino-1-phenyl pyrazoles BAYER AG (DE) 1987-09-09 EP disclosed