Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27494442 | 0.69 | ALDH1A1 (0.39) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| SCHEMBL70329 | 0.68 | ALDH1A1 (0.43) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| SCHEMBL9986878 | 0.68 | HSD17B10 (0.37) | ALDH1A1HSD17B10KDM4E | |
| SCHEMBL8733623 | 0.67 | ALDH1A1 (0.41) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| SCHEMBL8304145 | 0.65 | ALDH1A1 (0.44) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| Anthracene SCHEMBL28787108 | 0.65 | ALDH1A1 (0.53) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| SCHEMBL31025685 | 0.64 | ALDH1A1 (0.43) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| SCHEMBL28463321 | 0.62 | ALDH1A1 (0.56) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| SCHEMBL29423353 | 0.62 | ALDH1A1 (0.56) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 | |
| SCHEMBL190942 | 0.62 | ALDH1A1 (0.56) | NQO1ALDH1A1HIF1ACYP1B1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707579-B1 | PIPERIDINYL SUBSTITUTED METHANOANTHRACENES AS D1/D2-ANTAGONISTS AND 5HT2-SEROTANIN-ANTAGONISTS | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5681840-A | ANTIDOPAMINERGIC AGENTS | ZENECA LIMITED (GB) | 1997-10-28 | — | — | US | disclosed |
| US-5512575-A | ANTISEROTONINE AGENT | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| EP-0707579-A1 | PIPERIDINYL SUBSTITUTED METHANOANTHRACENES AS D1/D2-ANTAGONISTS AND 5HT2-SEROTANIN-ANTAGONISTS | ZENECA LIMITED (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001974-A1 | PIPERIDINYL SUBSTITUTED METHANOANTHRACENES AS D1/D2-ANTAGONISTS AND 5HT2-SEROTANIN-ANTAGONISTS | ZENECA LIMITED (GB) | 1995-01-19 | — | — | WO | disclosed |