Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 3/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | YAP1 | P46937 | 1/20 | 0.45 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.45 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6214071 | 0.91 | ALDH1A1 (0.51) | CYP2D6OPRK1CHRM2CHRM4CHRM1 | |
| SCHEMBL29598743 | 0.79 | ALDH1A1 (0.61) | CHRM2CHRM4CHRM1ALDH1A1KDM4E | |
| SCHEMBL6369662 | 0.79 | ALDH1A1 (0.49) | ALDH1A1KDM4EHTTEGLN1YAP1 | |
| SCHEMBL12489580 | 0.78 | ALDH1A1 (0.68) | OPRK1CHRM2CHRM4CHRM1ALDH1A1 | |
| SCHEMBL1828872 | 0.78 | ALDH1A1 (0.68) | OPRK1CHRM2CHRM4CHRM1ALDH1A1 | |
| SCHEMBL16973965 | 0.78 | ALDH1A1 (0.68) | OPRK1CHRM2CHRM4CHRM1ALDH1A1 | |
| SCHEMBL5013538 | 0.78 | ALDH1A1 (0.64) | CHRM2CHRM4CHRM1ALDH1A1KDM4E | |
| SCHEMBL8692376 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KDM4EHTTEGLN1YAP1 | |
| SCHEMBL5215264 | 0.77 | KDM4E (0.46) | CYP2D6OPRK1KDM4EEGLN1YAP1 | |
| SCHEMBL4577310 | 0.77 | FAAH (0.68) | ALDH1A1SMN1; SMN2RAB9ATACR3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0777649-B1 | N- 2-(PYRROLIDINYL-1)-1-PHENYLETHYL]ACETAMIDES AS KAPPA RECEPTOR AGONISTS | PFIZER (US) | 1999-07-14 | — | — | EP | disclosed |
| US-5837720-A | N-2-(pyrrolidinyl-1)-1-phenethyl) acetamides as kappa receptor antagonists | PFIZER INC. (US) | 1998-11-17 | — | — | US | disclosed |
| EP-0777649-A1 | N- 2-(PYRROLIDINYL-1)-1-PHENYLETHYL]ACETAMIDES AS KAPPA RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996006077-A1 | N-[2-(PYRROLIDINYL-1)-1-PHENYLETHYL]ACETAMIDES AS KAPPA RECEPTOR ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1996-02-29 | — | — | WO | disclosed |
| WO-1996006078-A1 | N-(2-(PYRROLIDINYL-1)-1-PHENYLETHYL)ACETAMIDES AS KAPPA RECEPTOR ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1996-02-29 | — | — | WO | disclosed |