Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304764 | 0.75 | KDM4E (0.46) | NPC1RAB9ASMN1; SMN2MAPTSYK | |
| SCHEMBL19154063 | 0.74 | TRIM24 (0.47) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL19153926 | 0.74 | ALDH1A1 (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1ALDH1A1 | |
| Hydrazine SCHEMBL29217437 | 0.72 | TRIM24 (0.44) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL3815268 | 0.71 | HRH3 (0.41) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3873496 | 0.71 | HRH1 (0.44) | RAB9ASMN1; SMN2MAPTALDH1A1KDM4E | |
| SCHEMBL8521451 | 0.70 | KDM4E (0.50) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL2301022 | 0.69 | DCTPP1 (0.48) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL27416808 | 0.68 | CHRM5 (0.44) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL9514491 | 0.67 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0892795-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997038992-A1 | PIPERIDINYLPYRAMIDINE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-10-23 | — | — | WO | disclosed |