Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307940 | 0.96 | CYP4F2 (0.43) | CYP4F2CYP4A11CYP4Z1RORCLMNA | |
| SCHEMBL8308677 | 0.91 | CYP4F2 (0.39) | CYP4F2CYP4A11CYP4Z1RORCLMNA | |
| SCHEMBL8304255 | 0.85 | TBXAS1 (0.47) | LMNATBXAS1 | |
| SCHEMBL8310033 | 0.84 | HDAC3 (0.42) | LMNAKMT2A | |
| SCHEMBL8308752 | 0.81 | TBXAS1 (0.56) | TBXAS1 | |
| SCHEMBL8309357 | 0.79 | TBXAS1 (0.58) | TBXAS1 | |
| SCHEMBL9183036 | 0.76 | TBXAS1 (0.66) | TBXAS1 | |
| SCHEMBL8304782 | 0.74 | TBXAS1 (0.46) | CYP4F2CYP4A11CYP4Z1TBXAS1FFAR1 | |
| SCHEMBL3175580 | 0.73 | CYP4F2 (0.57) | PPARGCYP4F2CYP4A11CYP4Z1FFAR1 | |
| SCHEMBL8308483 | 0.73 | CYP3A4 (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |