Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307940 | 0.95 | CYP4F2 (0.43) | CYP4F2CYP4A11LMNACYP4Z1SYK | |
| SCHEMBL8304781 | 0.91 | PPARG (0.40) | CYP4F2CYP4A11LMNACYP4Z1SYK | |
| SCHEMBL8304255 | 0.82 | TBXAS1 (0.47) | LMNAALDH1A1MAPT | |
| SCHEMBL8310033 | 0.81 | HDAC3 (0.42) | LMNAMAPT | |
| SCHEMBL8308752 | 0.80 | TBXAS1 (0.56) | — | |
| SCHEMBL8308679 | 0.74 | CYP4F2 (0.41) | CYP4F2CYP4A11LMNACYP4Z1ALDH1A1 | |
| SCHEMBL8308660 | 0.73 | TBXAS1 (0.49) | CYP4F2CYP4A11 | |
| SCHEMBL8308483 | 0.72 | CYP3A4 (0.45) | P2RY12 | |
| SCHEMBL8308006 | 0.72 | CYP4F2 (0.47) | CYP4F2CYP4A11LMNACYP4Z1SYK | |
| SCHEMBL8307041 | 0.71 | TBXAS1 (0.49) | CYP4F2CYP4A11LMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |