Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 13/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308752 | 0.92 | TBXAS1 (0.56) | TBXAS1TBXA2R | |
| SCHEMBL8309357 | 0.90 | TBXAS1 (0.58) | TBXAS1ALDH1A1MAPTTBXA2R | |
| SCHEMBL8307940 | 0.87 | CYP4F2 (0.43) | ALDH1A1LMNAMAPT | |
| SCHEMBL8304781 | 0.85 | PPARG (0.40) | TBXAS1LMNA | |
| SCHEMBL8310033 | 0.83 | HDAC3 (0.42) | LMNAMAPT | |
| SCHEMBL9183036 | 0.83 | TBXAS1 (0.66) | TBXAS1TBXA2R | |
| SCHEMBL8308677 | 0.82 | CYP4F2 (0.39) | ALDH1A1LMNAMAPT | |
| SCHEMBL8309142 | 0.81 | TBXAS1 (0.70) | TBXAS1ALDH1A1LMNATBXA2R | |
| SCHEMBL8306769 | 0.79 | TBXAS1 (0.63) | TBXAS1ALDH1A1LMNATDP1 | |
| SCHEMBL11106768 | 0.79 | ALDH1A1 (0.64) | TBXAS1ALDH1A1LMNAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |