Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 5/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304781 | 0.96 | PPARG (0.40) | CYP4F2CYP4A11LMNACYP4Z1SYK | |
| SCHEMBL8308677 | 0.95 | CYP4F2 (0.39) | CYP4F2CYP4A11LMNACYP4Z1SYK | |
| SCHEMBL8304255 | 0.87 | TBXAS1 (0.47) | LMNAALDH1A1MAPT | |
| SCHEMBL8310033 | 0.86 | HDAC3 (0.42) | LMNAMAPTHTT | |
| SCHEMBL8308752 | 0.85 | TBXAS1 (0.56) | — | |
| SCHEMBL8308483 | 0.76 | CYP3A4 (0.45) | P2RY12 | |
| SCHEMBL8593323 | 0.74 | CYP4F2 (0.48) | CYP4F2CYP4A11LMNACYP4Z1KDM4E | |
| SCHEMBL8309357 | 0.74 | TBXAS1 (0.58) | ALDH1A1MAPT | |
| SCHEMBL29026089 | 0.73 | LMNA (0.43) | LMNARORCKDM4EALDH1A1HSD17B10 | |
| SCHEMBL30288171 | 0.73 | LMNA (0.43) | LMNARORCKDM4EALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |