Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA4 | P22748 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10442103 | 0.80 | FFAR1 (0.41) | FFAR1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL28773528 | 0.78 | FFAR1 (0.40) | FFAR1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL15688668 | 0.78 | ALDH1A1 (0.53) | FFAR1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL6535306 | 0.77 | FFAR1 (0.39) | FFAR1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL8305078 | 0.76 | FFAR1 (0.40) | FFAR1MAPTALDH1A1KDM4ECYP3A4 | |
| SCHEMBL8307761 | 0.74 | TSHR (0.46) | FFAR1MAPTALDH1A1KDM4ECYP3A4 | |
| SCHEMBL436732 | 0.74 | MME (0.40) | HCAR2TAAR1 | |
| SCHEMBL8302074 | 0.74 | KCNH2 (0.44) | FFAR1ALDH1A1LMNAHCAR2TSHR | |
| SCHEMBL5312824 | 0.74 | ALDH1A1 (0.47) | FFAR1MAPTALDH1A1KDM4ELMNA | |
| SCHEMBL30912697 | 0.74 | CYP3A4 (0.59) | FFAR1MAPTALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018157800-A1 | MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2018-09-07 | — | — | WO | disclosed |