Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305768 | 0.90 | ALDH1A1 (0.43) | ALDH1A1TSHRTDP1CYP19A1CYP11B1 | |
| SCHEMBL2991924 | 0.82 | MAPT (0.51) | ALDH1A1HPGDMAPTKMT2AMEN1 | |
| SCHEMBL6788264 | 0.78 | LMNA (0.54) | ALDH1A1MAPTKMT2AKDM4ELMNA | |
| SCHEMBL29739542 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1CYP19A1MAPT | |
| SCHEMBL1979913 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TSHRTDP1CYP19A1MAPT | |
| SCHEMBL8310019 | 0.77 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTKDM4ELMNA | |
| SCHEMBL6187792 | 0.75 | ALDH1A1 (0.54) | ALDH1A1CYP19A1CYP11B1CYP11B2MAPT | |
| SCHEMBL29503009 | 0.74 | MEN1 (0.65) | ALDH1A1TSHRTDP1CYP19A1CYP11B1 | |
| SCHEMBL5226904 | 0.74 | MEN1 (0.65) | ALDH1A1TSHRTDP1CYP19A1CYP11B1 | |
| SCHEMBL9995366 | 0.71 | ALDH1A1 (0.50) | ALDH1A1TSHRTDP1CYP19A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |