Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305760 | 0.90 | ALDH1A1 (0.43) | ALDH1A1TDP1TSHRKMT2AMEN1 | |
| SCHEMBL2991924 | 0.85 | MAPT (0.51) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL29151328 | 0.79 | ALDH1A1 (0.47) | ALDH1A1TDP1TSHRKMT2AMEN1 | |
| SCHEMBL6788264 | 0.78 | LMNA (0.54) | ALDH1A1KMT2AMAPTLMNAKDM4E | |
| SCHEMBL8946550 | 0.77 | ALDH1A1 (0.56) | ALDH1A1TDP1TSHRKMT2AMEN1 | |
| SCHEMBL8310026 | 0.77 | ALDH1A1 (0.42) | ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL22381241 | 0.76 | ALDH1A1 (0.58) | ALDH1A1TDP1TSHRKMT2AMAPT | |
| SCHEMBL6187801 | 0.75 | KMT2A (0.51) | ALDH1A1KMT2AMEN1MAPTLMNA | |
| SCHEMBL6068707 | 0.75 | S1PR4 (0.44) | ALDH1A1TDP1TSHRKMT2AMEN1 | |
| SCHEMBL30354907 | 0.75 | EPHX2 (0.59) | ALDH1A1TSHRKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |