Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PTPRE | P23469 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | YES1 | P07947 | 1/20 | 0.36 |
| ▸ | FECH | P22830 | 1/20 | 0.36 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.36 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310019 | 0.88 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTCYP2C19RAB9A | |
| SCHEMBL2986980 | 0.82 | EGFR (0.44) | ALDH1A1HPGDMAPTCYP2C19RAB9A | |
| SCHEMBL12851558 | 0.81 | KDM4E (0.48) | ALDH1A1MAPTRAB9AL3MBTL1KDM4E | |
| SCHEMBL13950793 | 0.80 | SLC6A3 (0.40) | ALDH1A1HPGDMAPTRAB9AL3MBTL1 | |
| SCHEMBL8305768 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4ENPC1 | |
| SCHEMBL5569854 | 0.76 | ALDH1A1 (0.37) | ALDH1A1MAPTCYP2C19KDM4EGAA | |
| SCHEMBL30354882 | 0.75 | SYK (0.43) | ALDH1A1MAPTRAB9AL3MBTL1KDM4E | |
| SCHEMBL6795023 | 0.74 | CYP2C19 (0.48) | ALDH1A1MAPTCYP2C19RAB9AL3MBTL1 | |
| SCHEMBL23136479 | 0.73 | L3MBTL1 (0.47) | ALDH1A1HPGDMAPTCYP2C19RAB9A | |
| SCHEMBL10056869 | 0.73 | KDM4E (0.61) | ALDH1A1HPGDMAPTRAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |