SCHEMBL8305850

SCHEMBL8305850

Nc1noc2cc(OCc3ccccc3)ccc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 10/20 0.52
ACHE P22303 1/20 0.51
MAOA P21397 4/20 0.50
RAB9A P51151 3/20 0.50
NPC1 O15118 3/20 0.50
TDP1 Q9NUW8 3/20 0.50
CASP3 P42574 1/20 0.50
SENP8 Q96LD8 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
SENP6 Q9GZR1 1/20 0.50
GAA P10253 1/20 0.49
MAPT P10636 1/20 0.49
SMN1; SMN2 Q16637 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
MEN1 O00255 1/20 0.48
CA12 O43570 1/20 0.48
CA1 P00915 1/20 0.48
CA2 P00918 1/20 0.48
CA3 P07451 1/20 0.48
CA4 P22748 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8291371 0.83 MAOB (0.52) MAOBACHEMAOARAB9ANPC1
SCHEMBL4306909 0.80 MAOB (0.52) MAOBACHEMAOARAB9ANPC1
SCHEMBL21596857 0.79 HTR3A (0.47) MAOBMAOARAB9ANPC1TDP1
SCHEMBL16059525 0.79 CYP2D6 (0.47) MAOBRAB9ANPC1TDP1MAPT
SCHEMBL6931962 0.78 TEC (0.50) MAOBACHEMAOAMAPTAR
SCHEMBL17338654 0.78 CASP3 (0.54) MAOBACHEMAOARAB9ANPC1
SCHEMBL8304336 0.77 MAOB (0.51) MAOBACHEMAOARAB9ANPC1
SCHEMBL15145315 0.77 LTB4R (0.49) MAOBMAOACA12CA1CA2
SCHEMBL18640063 0.76 LTB4R (0.48) MAOBACHEMAOARAB9ANPC1
SCHEMBL31535768 0.76 CTSV (0.46)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0835254-B1 OXAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL USE SYNTHELABO (FR) 1999-09-01 EP disclosed
US-5843975-A Oxazolidinone derivatives, their preparation and therapeutical use SYNTHELABO (FR) 1998-12-01 US disclosed
EP-0835254-A1 OXAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL USE SYNTHELABO (FR) 1998-04-15 EP disclosed
WO-1996038444-A1 OXAZOLIDINONE DERIVATIVES, THEIR PREPARATION AND THERAPEUTICAL USE SYNTHELABO (FR) 1996-12-05 WO disclosed