Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | REN | P00797 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | CBX7 | O95931 | 1/20 | 0.50 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.50 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.50 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16264966 | 0.84 | DRD2 (0.58) | DRD2HTR2AMCHR1L3MBTL1SMPD1 | |
| SCHEMBL30336446 | 0.83 | REN (0.49) | DRD2HTR2AMCHR1L3MBTL1SMPD1 | |
| SCHEMBL29209067 | 0.83 | REN (0.49) | DRD2HTR2AMCHR1L3MBTL1SMPD1 | |
| SCHEMBL4602089 | 0.83 | REN (0.49) | DRD2HTR2AMCHR1L3MBTL1SMPD1 | |
| SCHEMBL1047741 | 0.83 | REN (0.57) | DRD2HTR2AMCHR1POLBKMT2A | |
| SCHEMBL89401 | 0.83 | TSHR (0.71) | POLBALDH1A1MEN1KMT2AREN | |
| SCHEMBL4058329 | 0.82 | ALDH1A1 (0.56) | DRD2HTR2AMCHR1L3MBTL1SMPD1 | |
| SCHEMBL8306331 | 0.82 | REN (0.56) | DRD2HTR2AMCHR1SMPD1POLB | |
| SCHEMBL15423258 | 0.82 | DRD2 (0.56) | DRD2HTR2AMCHR1L3MBTL1SMPD1 | |
| SCHEMBL6508989 | 0.82 | REN (0.56) | DRD2HTR2AMCHR1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |