Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 8/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 2/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308276 | 0.83 | TBXAS1 (0.49) | TBXAS1 | |
| SCHEMBL8309308 | 0.82 | TBXAS1 (0.60) | TBXAS1 | |
| SCHEMBL8701897 | 0.81 | TBXAS1 (0.49) | TBXAS1 | |
| SCHEMBL8308944 | 0.78 | TBXAS1 (0.57) | TBXAS1 | |
| SCHEMBL9382024 | 0.77 | TBXAS1 (0.43) | TBXAS1 | |
| SCHEMBL8307381 | 0.77 | TBXAS1 (0.50) | TBXAS1CYP3A4 | |
| SCHEMBL8307374 | 0.77 | TBXAS1 (0.48) | TBXAS1 | |
| SCHEMBL30336917 | 0.75 | CYP3A4 (0.53) | CYP3A4 | |
| SCHEMBL29059890 | 0.73 | TBXAS1 (0.51) | TBXAS1CYP3A4 | |
| SCHEMBL8307372 | 0.73 | TBXAS1 (0.53) | TBXAS1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0579618-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | Pfizer Limited (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017451-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LIMITED (GB) | 1992-10-15 | — | — | WO | disclosed |