Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8303980 | 1.00 | NPC1 (0.48) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8609779 | 0.80 | ALOX5 (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1298504 | 0.76 | NPC1 (0.70) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14352146 | 0.76 | NPC1 (0.70) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8609455 | 0.75 | NPC1 (0.43) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4729170 | 0.73 | NPC1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8609409 | 0.73 | NPC1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4729172 | 0.73 | NPC1 (0.45) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8550159 | 0.72 | NPC1 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8307478 | 0.72 | NPC1 (0.62) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832078-B1 | N-HYDROXYUREAS AS ANTIINFLAMMATORY AGENTS | PFIZER (US) | 1999-10-20 | — | — | EP | disclosed |