Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | KIT | P10721 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.56 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19354052 | 0.95 | FLT3 (0.67) | FLT3MEN1NPC1MAPTRAB9A | |
| SCHEMBL8304151 | 0.85 | PARP1 (0.56) | FLT3MEN1NPC1MAPTRAB9A | |
| SCHEMBL5276648 | 0.85 | ALDH1A1 (0.54) | FLT3MEN1NPC1MAPTRAB9A | |
| SCHEMBL9035685 | 0.84 | FLT3 (0.50) | FLT3MEN1NPC1MAPTRAB9A | |
| SCHEMBL8305265 | 0.83 | CYP1B1 (0.65) | FLT3MEN1NPC1MAPTKMT2A | |
| SCHEMBL10001096 | 0.82 | FLT3 (0.72) | FLT3MEN1NPC1MAPTRAB9A | |
| SCHEMBL8308052 | 0.81 | MAOB (0.67) | FLT3MEN1NPC1MAPTRAB9A | |
| SCHEMBL8306599 | 0.81 | FLT3 (0.47) | FLT3MEN1NPC1MAPTRAB9A | |
| SCHEMBL38654550 | 0.81 | ABCG2 (0.75) | FLT3MEN1MAPTKMT2AMAOB | |
| SCHEMBL19354056 | 0.79 | PDE5A (0.61) | FLT3MEN1NPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |