Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.56 |
| ▸ | PDE5A | O76074 | 2/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 3/20 | 0.53 |
| ▸ | AKT1 | P31749 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | CDK8 | P49336 | 2/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19354056 | 0.95 | PDE5A (0.61) | PARP1PARP2PDE5AESR1PDE4D | |
| SCHEMBL5276648 | 0.88 | ALDH1A1 (0.54) | PARP1PARP2APPMAOBCYP19A1 | |
| SCHEMBL8307487 | 0.85 | FLT3 (0.61) | APPAKT1MAOBCYP19A1ALDH1A1 | |
| SCHEMBL4227433 | 0.83 | PDE5A (0.80) | PARP1PARP2PDE5AESR1PDE4D | |
| SCHEMBL8308207 | 0.82 | AKT1 (0.61) | PARP1PARP2PDE5AESR1PDE4D | |
| SCHEMBL19353997 | 0.82 | PARP1 (0.65) | PARP1PARP2PDE5AESR1PDE4D | |
| SCHEMBL8429382 | 0.81 | ALDH1A1 (0.49) | PARP1PARP2APPMAOBCYP19A1 | |
| SCHEMBL8308052 | 0.80 | MAOB (0.67) | MAOBCYP19A1ALDH1A1MAPK1CDK8 | |
| SCHEMBL19354052 | 0.79 | FLT3 (0.67) | AKT1MAOBCYP19A1ALDH1A1MAPK1 | |
| SCHEMBL19354126 | 0.77 | PARP1 (0.60) | PARP1PARP2PDE5AESR1PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709383-B1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1999-12-15 | — | — | EP | disclosed |
| EP-0709383-A1 | Diosmetin derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-05-01 | — | — | EP | disclosed |