Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | HTR2A | P28223 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308708 | 0.90 | HTR2A (0.37) | HTR1ADRD2HTR2A | |
| SCHEMBL8306729 | 0.80 | DRD4 (0.39) | HTR2A | |
| SCHEMBL8303832 | 0.79 | DRD4 (0.39) | HTR1ADRD2HTR2A | |
| SCHEMBL10415353 | 0.78 | DRD3 (0.48) | HTR1ADRD2HTR2A | |
| SCHEMBL9778381 | 0.78 | SMO (0.44) | — | |
| Hydrochloric Acid SCHEMBL9778468 | 0.77 | DRD3 (0.47) | HTR1ADRD2HTR2A | |
| SCHEMBL1545677 | 0.77 | HTR1A (0.43) | HTR1ADRD2HTR2A | |
| Hydrochloric Acid SCHEMBL1545847 | 0.76 | HTR1A (0.43) | HTR1ADRD2HTR2A | |
| SCHEMBL27331552 | 0.73 | TLR7 (0.46) | HTR1ADRD2HTR2A | |
| Fumaric Acid SCHEMBL8854165 | 0.73 | HTR1A (0.40) | HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5041445-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-20 | — | — | US | disclosed |