Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9759749 | 0.86 | PARP1 (0.46) | HTR2ADRD2DRD3HTR7HTR1A | |
| SCHEMBL8302347 | 0.81 | DRD4 (0.43) | DRD4HTR2A | |
| SCHEMBL8303565 | 0.81 | CYP2D6 (0.34) | HTR2A | |
| SCHEMBL8308708 | 0.79 | HTR2A (0.37) | DRD4HTR2ADRD2HTR1A | |
| SCHEMBL8307627 | 0.79 | HTR1A (0.37) | HTR2ADRD2HTR1A | |
| SCHEMBL9778524 | 0.78 | HTR2A (0.44) | HTR2ADRD2DRD3HTR7HTR1A | |
| SCHEMBL8304798 | 0.78 | DRD4 (0.44) | DRD4HTR2A | |
| SCHEMBL8307680 | 0.78 | HTR2A (0.65) | DRD4HTR2ADRD2HTR7 | |
| SCHEMBL7990176 | 0.77 | DRD4 (0.45) | DRD4HTR2AADRA1BDRD2DRD3 | |
| SCHEMBL8303613 | 0.77 | DRD4 (0.43) | DRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | claimed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | claimed |
| US-5041445-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-20 | — | — | US | claimed |
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |