Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.37 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307627 | 0.90 | HTR1A (0.37) | HTR2AHTR1ADRD2 | |
| SCHEMBL8304843 | 0.80 | DRD4 (0.42) | HTR2ADRD4 | |
| SCHEMBL8303832 | 0.79 | DRD4 (0.39) | HTR2AHTR1ADRD2DRD4 | |
| SCHEMBL7990176 | 0.74 | DRD4 (0.45) | HTR2ADRD2DRD4 | |
| SCHEMBL8306729 | 0.70 | DRD4 (0.39) | HTR2ADRD4 | |
| SCHEMBL9759749 | 0.69 | PARP1 (0.46) | HTR2AHTR1ADRD2 | |
| SCHEMBL7990198 | 0.69 | HTR1A (0.63) | HTR2AHTR1ADRD2 | |
| SCHEMBL7997114 | 0.68 | HTR1A (0.60) | HTR2AHTR1ADRD2 | |
| Oxalic Acid SCHEMBL7993398 | 0.66 | KDM4E (0.63) | HTR1ADRD2DRD4 | |
| SCHEMBL10415353 | 0.66 | DRD3 (0.48) | HTR2AHTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458234-B1 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0458234-A2 | 3-[1,Thiazolidinylbutyl-4-piperazinyl]-1H-indazoles, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5041445-A | Antipsychotic agents | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-08-20 | — | — | US | disclosed |