Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 1/20 | 0.57 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.57 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.57 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.57 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.57 |
| ▸ | SCN4A | P35499 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285675 | 0.81 | GRM5 (0.53) | SMN1; SMN2GRM5KDM1AMAOAMAOB | |
| SCHEMBL7027270 | 0.80 | NOS2 (0.45) | SMN1; SMN2NOS2NOS1KDM1AMAOA | |
| SCHEMBL11083185 | 0.79 | LMNA (0.46) | SMN1; SMN2NOS2NOS1GRM5KDM1A | |
| SCHEMBL20897039 | 0.78 | TAAR1 (0.47) | NOS2MAOANOS3 | |
| SCHEMBL14592093 | 0.76 | SMN1; SMN2 (0.42) | SMN1; SMN2GRM5KDM1AMAOAMAOB | |
| SCHEMBL20032025 | 0.75 | NOS3 (0.41) | SMN1; SMN2NOS2KDM1AMAOAMAOB | |
| SCHEMBL9371930 | 0.74 | GRIN2D (0.51) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL6813780 | 0.74 | GRIN2D (0.51) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL2614966 | 0.74 | KDM4E (0.46) | SMN1; SMN2NOS2NOS1GRM5KDM1A | |
| Hydrochloric Acid SCHEMBL8862842 | 0.73 | GRIN2D (0.50) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612314-B1 | 2-PYRAZINYLETHYLAMINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | ASTRA AB (SE) | 1999-12-29 | — | — | EP | disclosed |
| US-5607935-A | 2-heterocyclicethylamine derivatives and their use as pharmaceuticals | FISONS CORPORATION (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0612314-A1 | 2-HETEROCYCLICETHYLAMINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | Astra Aktiebolag (SE) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993009095-A1 | 2-HETEROCYCLICETHYLAMINE DERIVATIVES AND THEIR USE AS PHARMACEUTICALS | FISONS CORPORATION (US) | 1993-05-13 | — | — | WO | disclosed |
| EP-0540318-A1 | 2-Heterocyclicethylamine derivatives and their use as pharmaceuticals | FISONS CORPORATION (US) | 1993-05-05 | — | — | EP | disclosed |