Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | ATR | Q13535 | 1/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 10/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307211 | 0.92 | CA12 (0.57) | PRKDCATMATRCA12CA1 | |
| SCHEMBL8521718 | 0.91 | KDM4E (0.58) | PRKDCATMATRCA12CA1 | |
| SCHEMBL8305443 | 0.86 | CA12 (0.72) | PRKDCATMATRCA12CA1 | |
| SCHEMBL8306288 | 0.81 | PRKDC (0.55) | PRKDCATMATRCA12CA1 | |
| SCHEMBL30292823 | 0.79 | PTGS2 (0.60) | PRKDCATMATRCA12CA1 | |
| SCHEMBL25726938 | 0.79 | PTGS2 (0.50) | PRKDCATMATRCA12CA1 | |
| SCHEMBL8306238 | 0.75 | CDK5 (0.60) | PRKDCATMATRCA12CA1 | |
| SCHEMBL28929657 | 0.73 | CA2 (0.77) | PRKDCATMATRCA12CA1 | |
| SCHEMBL25727641 | 0.72 | CYP19A1 (0.55) | PRKDCATMATRCA12CA1 | |
| SCHEMBL10997079 | 0.71 | RAB9A (0.71) | CA12CA1CA2CA9CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915848-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1999-05-19 | — | — | EP | disclosed |
| WO-1998005639-A1 | 1,2-DIARYLINDOLE AS COX-2 INHIBITORS | LABORATOIRES UPSA (FR) | 1998-02-12 | — | — | WO | disclosed |