Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768941 | 0.78 | SIGMAR1 (0.55) | KDM4ETAAR1MAPTALDH1A1HSD17B10 | |
| SCHEMBL8440692 | 0.78 | MAPT (0.74) | TAAR1MAPTALDH1A1POLBTSHR | |
| SCHEMBL6768523 | 0.77 | KDM4E (0.50) | KDM4ETAAR1MAPTALDH1A1HSD17B10 | |
| SCHEMBL6720679 | 0.72 | ALDH1A1 (0.55) | KDM4EMAPTALDH1A1HSD17B10CYP2C19 | |
| SCHEMBL8300580 | 0.71 | MAPT (0.49) | KDM4ETAAR1MAPTALDH1A1CYP2C19 | |
| SCHEMBL8330596 | 0.70 | GAA (0.48) | KDM4ETAAR1MAPTALDH1A1HSD17B10 | |
| Hydrochloric Acid SCHEMBL6929672 | 0.70 | CHRM2 (0.58) | KDM4ETAAR1MAPTALDH1A1CHRM2 | |
| SCHEMBL8335230 | 0.70 | NOTUM (0.48) | KDM4ETAAR1MAPTALDH1A1HSD17B10 | |
| SCHEMBL7103078 | 0.67 | ALDH1A1 (0.53) | KDM4EMAPTALDH1A1HSD17B10CYP2C19 | |
| Hydrochloric Acid SCHEMBL6770312 | 0.66 | KDM4E (0.45) | KDM4ETAAR1MAPTALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925300-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-30 | — | — | EP | disclosed |
| EP-0925300-A4 | — | — | 1999-06-30 | — | — | EP | disclosed |
| WO-1997030054-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-08-21 | — | — | WO | disclosed |