SCHEMBL8307876

SCHEMBL8307876

COc1onc(C)c1C(=O)O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.38
CA12 O43570 1/20 0.35
CA1 P00915 1/20 0.35
CA2 P00918 1/20 0.35
CA7 P43166 1/20 0.35
CA9 Q16790 1/20 0.35
CA14 Q9ULX7 1/20 0.35
HCAR2 Q8TDS4 1/20 0.34
KDM4E B2RXH2 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
GAA P10253 3/20 0.34
POLB P06746 2/20 0.34
CNR2 P34972 1/20 0.34
FTO Q9C0B1 1/20 0.34
ALDH1A1 P00352 3/20 0.33
HPGD P15428 3/20 0.33
TSHR P16473 2/20 0.33
NPSR1 Q6W5P4 1/20 0.33
MAPT P10636 1/20 0.33
RECQL P46063 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL223413 0.74 GAA (0.49) KDM4EL3MBTL1GAAALDH1A1TSHR
Hydrochloric Acid SCHEMBL19119186 0.72 GAA (0.47) KDM4EL3MBTL1GAAALDH1A1TSHR
SCHEMBL354660 0.72 TSHR (0.39) HTTHCAR2KDM4EL3MBTL1GAA
SCHEMBL8305745 0.71 ALDH1A1 (0.39) HCAR2L3MBTL1GAAPOLBFTO
SCHEMBL938250 0.71 CYP1A2 (0.49) HTTHCAR2KDM4EL3MBTL1GAA
SCHEMBL21806565 0.71 HCAR2 (0.36) HTTHCAR2KDM4EL3MBTL1GAA
SCHEMBL9199743 0.71 HTT (0.48) HTTKDM4EPOLBCNR2ALDH1A1
SCHEMBL4340596 0.70 ALDH1A1 (0.55) CA1CA2KDM4EGAAPOLB
SCHEMBL9199700 0.69 POLB (0.45) HCAR2KDM4EL3MBTL1GAAPOLB
SCHEMBL2718249 0.69 ALDH1A1 (0.38) HTTGAAPOLBCNR2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0777666-B1 SUBSTITUTED PIPERIDINES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES MERRELL PHARMA INC (US) 1999-03-03 EP claimed
EP-0695748-B1 Tetrazolinone herbicides BAYER AGROCHEM KK (JP) 1999-05-06 EP disclosed
US-5589439-A HERBICIDES NIHON BAYER AGROCHEM K.K. (JP) 1996-12-31 US disclosed
EP-0695748-A1 Tetrazolinone herbicides NIHON BAYER AGROCHEM K.K. (JP) 1996-02-07 EP disclosed