Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | DGKA | P23743 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PAM | P19021 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179158 | 0.91 | — | — | |
| Chloroform SCHEMBL8309332 | 0.88 | TSHR (0.49) | ALDH1A1TSHRCYP3A4ATMTDP1 | |
| Chloroform SCHEMBL8310130 | 0.86 | DGKA (0.57) | ALDH1A1TSHRCYP3A4ATMTDP1 | |
| Chloroform SCHEMBL8307778 | 0.84 | DGKA (0.60) | ALDH1A1TSHRCYP3A4ATMTDP1 | |
| SCHEMBL8680864 | 0.77 | — | — | |
| SCHEMBL10835316 | 0.77 | TSHR (0.46) | ALDH1A1TSHRCYP3A4ATMTDP1 | |
| SCHEMBL3607268 | 0.76 | ALDH1A1 (0.48) | ALDH1A1TSHRCYP3A4ATMTDP1 | |
| SCHEMBL6893576 | 0.76 | DGKA (0.65) | ALDH1A1TSHRCYP3A4ATMTDP1 | |
| Chloroform SCHEMBL28849375 | 0.75 | ALDH1A1 (0.52) | ALDH1A1TSHRDGKALMNAMAPT | |
| SCHEMBL2182828 | 0.74 | DGKA (0.69) | ALDH1A1TSHRCYP3A4ATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5914339-A | ANTI-DIABETIC AND/OR ANTIHYPERGLYCEMIA AND/OR ANTI-OBESITY AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-06-22 | — | — | US | disclosed |
| EP-0901484-A1 | SUBSTITUTED 1, 3-BENZODIOXOLES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043273-A1 | SUBSTITUTED 1, 3-BENZODIOXOLES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-11-20 | — | — | WO | disclosed |