Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.44 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308827 | 1.00 | GABRA1 (0.44) | GABRA1GABRG2GABRB3GABRB2TDP1 | |
| SCHEMBL1876606 | 0.82 | ALDH1A1 (0.41) | TDP1MAPK1GAALMNAPOLB | |
| SCHEMBL1876605 | 0.82 | ALDH1A1 (0.41) | TDP1MAPK1GAALMNAPOLB | |
| SCHEMBL8234794 | 0.82 | ALDH1A1 (0.41) | TDP1MAPK1GAALMNAPOLB | |
| SCHEMBL18956039 | 0.82 | MAPK1 (0.45) | GABRA1GABRG2GABRB3GABRB2TDP1 | |
| SCHEMBL18956042 | 0.82 | MAPK1 (0.45) | GABRA1GABRG2GABRB3GABRB2TDP1 | |
| SCHEMBL8317042 | 0.77 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL8317039 | 0.77 | GABRA1 (0.45) | GABRA1GABRG2GABRB3GABRB2TSHR | |
| SCHEMBL4657618 | 0.74 | GABRA1 (0.56) | GABRA1GABRG2GABRB3GABRB2MAPK1 | |
| SCHEMBL11539748 | 0.72 | TSHR (0.48) | TDP1MAPK1GAAGFERLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922741-A | 5-aminopyrazoles useful as tyrosine kinase inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0906286-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997040019-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |