Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 9/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307025 | 0.90 | TBXAS1 (0.75) | TBXAS1ALDH1A1LMNAHTTMEN1 | |
| SCHEMBL8308578 | 0.89 | TBXAS1 (0.77) | TBXAS1TSHR | |
| SCHEMBL11106768 | 0.84 | ALDH1A1 (0.64) | TBXAS1TDP1ALDH1A1LMNAHTT | |
| SCHEMBL8307474 | 0.84 | TBXAS1 (0.58) | TBXAS1ALDH1A1HTTMEN1KMT2A | |
| SCHEMBL8306012 | 0.83 | TBXAS1 (0.79) | TBXAS1TSHR | |
| SCHEMBL8304690 | 0.82 | TBXAS1 (0.78) | TBXAS1TDP1ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8309271 | 0.82 | TBXAS1 (0.79) | TBXAS1ALDH1A1LMNATSHR | |
| SCHEMBL8310272 | 0.81 | TBXAS1 (0.77) | TBXAS1 | |
| SCHEMBL8305660 | 0.81 | TBXAS1 (0.77) | TBXAS1TSHR | |
| SCHEMBL8309158 | 0.81 | TBXAS1 (0.77) | TBXAS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0579618-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | Pfizer Limited (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017451-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LIMITED (GB) | 1992-10-15 | — | — | WO | disclosed |